10-08-2025, 03:24 PM
(10-07-2025, 04:00 AM)Blam Wrote: Can we do anything to lower HMGB1 naturally for now?
Chatgpt have this to say:
Natural Ways to Lower the “Aging Protein” (HMGB1)
Scientists recently discovered that a blood protein called HMGB1 may help spread aging through the body. When they blocked it in animals, damaged tissues started healing, and some age-related decline reversed.
But here’s the good news — lifestyle also affects this protein. You don’t need injections to start protecting yourself. These foods and habits can help lower HMGB1 naturally and keep your body younger for longer ?
? Foods That Help
Turmeric (Curcumin): Strong natural HMGB1 blocker. Add to soups or tea.
Ginger: Calms inflammation and stress in cells.
Garlic: Boosts immunity and reduces toxic buildup.
Leafy greens: Ugu, moringa, spinach, bitter leaf — all rich in antioxidants.
Berries: Blueberry, strawberry, blackberry — fight aging at the cell level.
Green tea: Contains EGCG, which helps quiet HMGB1 signals.
Fish & flaxseed: Omega-3 fats that fight inflammation.
Tomatoes & carrots: Lycopene and beta-carotene keep tissues young.
Onions: Quercetin helps reduce HMGB1 activity.
Fermented foods: Yogurt, kefir, ogiri, iru — heal your gut and reduce body-wide inflammation.
? Helpful Herbs & Natural Remedies
Black seed (Nigella sativa): Fights inflammation caused by HMGB1.
Resveratrol (in grapes, peanuts): Proven to calm aging signals in lab studies.
Moringa & bitter leaf: Natural detox and antioxidant herbs.
Aloe vera: Soothes inflammation and supports tissue repair.
? Healthy Habits That Protect You
Exercise moderately — it lowers HMGB1 and boosts repair.
Sleep well — poor sleep raises aging proteins.
Manage stress — peace of mind keeps inflammation down.
Quit smoking & reduce alcohol — both increase HMGB1 sharply.
Eat less processed food and sugar — they make aging signals worse.
Try intermittent fasting — it helps the body recycle damaged cells.
Stay hydrated and rest properly.
? Tip: You don’t need all of these at once. Just pick a few and stay consistent.
The goal is to reduce body inflammation — because once inflammation goes down, HMGB1 also goes down.
That’s how you start aging slower — from the inside out.

