10-07-2025, 12:00 AM
@Farmlady, Yes, lifestyle does seem to affect HMGB1 levels.
Research shows that HMGB1 isn’t just linked to aging — it’s also released more during stress, inflammation, poor diet, infections, and tissue damage. So things that cause chronic inflammation or oxidative stress (like smoking, junk food, alcohol, and lack of sleep) can increase HMGB1 activity.
On the other hand, healthy habits — like exercise, antioxidants (fruits, veggies, herbs like turmeric and ginger), good sleep, and stress control — help reduce HMGB1 release or keep it in its “normal” form that doesn’t spread damage.
Research shows that HMGB1 isn’t just linked to aging — it’s also released more during stress, inflammation, poor diet, infections, and tissue damage. So things that cause chronic inflammation or oxidative stress (like smoking, junk food, alcohol, and lack of sleep) can increase HMGB1 activity.
On the other hand, healthy habits — like exercise, antioxidants (fruits, veggies, herbs like turmeric and ginger), good sleep, and stress control — help reduce HMGB1 release or keep it in its “normal” form that doesn’t spread damage.